Ole Gunnar Solskjaer has a defensive conundrum on his hands this weekend in the Premier League.
Raphael Varane has been ruled out for two weeks while Harry Maguire is also a major doubt as Manchester United travel to Leicester.
It is the start of a tough few weeks of fixtures for the Red Devils, who will take on Manchester City, Chelsea and Arsenal in the coming weeks.
For United, it is critical they get off to a good start after losing confidence prior to the international break but without their top centre-backs, that could be tough.
So how could Solskjaer line up his side ahead of the weekend? Mirror Football takes a closer look.
The obvious solution to the Norwegian's problems is to use his back-up options in defence – Eric Bailly and Victor Lindelof.
However, United have rarely been in control of matches when the two start – the last high-profile match being the Europa League final.
On that occasion, the Red Devils lost on penalties despite being heavy favourites to finally win a trophy under Solskjaer.
The ex-Molde coach might, therefore, be tempted to use a different solution and that could include a change in personnel.
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In the past, former United boss Jose Mourinho has opted to use Scott McTominay in that role while he also has played there for Scotland, who has insisted the position is "second nature" to him.
The 24-year-old said: "The day before I knew I was playing there and the personnel who would be playing.
"It’s second nature now. I’ve played there before so you should know the role.
"Especially with this manager. I’ve played there before for him and done okay so you can adapt and do the best you can."
There is, however, a third option that Solskjaer could go with – a change in formation.
In the past, it has not worked out so well but that does not mean to abandon the idea completely with McTominay, Bailly and Lindelof together in a back-three.
Aaron Wan-Bissaka and Luke Shaw would be utilised as wing-backs but it could mean dropping an attacker further forward.
The last time Solskjaer used that formation, it failed as Young Boys beat them in the Champions League – though they were a man down.
But that could contain Leicester's high-octane style as best as United can – especially without Varane and Maguire.
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