Manchester United welcome Chelsea to Old Trafford looking to build on two straight wins in the past week.
But manager Ole Gunnar Solskjaer has some decisions to make, with Edinson Cavani, Axel Tuanzebe, Harry Maguire and Mason Greenwood all pushing for starts.
Cavani is in contention to make his Red Devils debut having had to go through quarantine and build his fitness following his arrival on transfer deadline day.
But Greenwood is also expected to be available following his recent injury, and the 19-year-old could start up front alongside Marcus Rashford, with Cavani an option from the bench.
United also hope Maguire will be fit to resume his place in central defence after he missed the 2-1 Champions League win over Paris-Saint Germain in midweek.
Axel Tuanzebe excelled against PSG in the absence of Maguire and Eric Bailly, and will be champing at the bit for another start.
However, Tuesday's game was his first in 10 months following his own injury problems, and Solskjaer will be conscious of not overloading the 22-year-old so soon into his comeback.
The manager will no doubt put his faith in Tuanzebe again if Maguire suffers a setback, but otherwise the England under-21 international may have to wait for his next chance to impress.
One aspect of Tuesday's win which looks set to remain is the three-man rearguard, which helped to address recent defensive vulnerabilities while giving deadline-day signing Alex Telles a licence to showcase his attacking talents.
So Maguire looks set to be joined by Victor Lindelof and Luke Shaw in defence, with Telles as a left wing-back and Aaron-Wan Bissaka on the opposite flank.
In midfield, Paul Pogba could come in for Scott McTominay, with Fred keeping his place following his performances in Tuesday's victory over PSG and last weekend's 4-1 win at Newcastle.
Bruno Fernandes will start in the No10 role behind Rashford and Greenwood.
Anthony Martial played up front against PSG but is suspended for Saturday's game, while centre-back Bailly and midfielder Jesse Lingard are not expected back until after next month's international break and Phil Jones is out with a long-term knee injury.
Frank Lampard's Chelsea will be looking to kick-start their season after draws against Sevilla and Southampton in the past week.
Winger Hakim Ziyech could make his first start after two appearances as a substitute since his £36million switch from Ajax.
Goalkeeper Kepa Arrizabalaga is sidelined with a shoulder injury – allowing Edouard Mendy to further cement his claim as the club's new No1 – while midfielder Billy Gilmour is Lampard's only other absentee with a knee injury.
Man Utd team (probable) vs Chelsea, Saturday October 24, 5.30pm, Old Trafford
Man Utd (3-4-1-2): De Gea; Lindelof, Maguire, Shaw; Wan-Bissaka, Fred, Pogba, Telles; Fernandes; Greenwood, Rashford.
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