Owen Farrell releases the ball during an England team training session at The Lensbury in Teddington
Beno Obano is the only uncapped player in the 23 and the Bath loosehead will make his debut if he comes on for Genge.
England will face Scotland for the 139th time in a match that marks 150 years since the rivals clashed in the first ever international rugby match.
“We’re really looking forward to this game and getting the Six Nations back underway. It’s even more special to be taking part in a 150th anniversary game, it will be a good occasion,” Jones said.
“It was difficult to pick the 23 players. We’ve had a really good week of training, it’s been very competitive but I’ve gone with what I feel is the strongest 23 for this week.
“The Six Nations is a short tournament, it’s a real sprint so we’ll need to be on the front foot straight away. We know Scotland will be raring to go – but so will we.”
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Eddie Jones talks to Billy Vunipola
England team vs Scotland
15. Elliot Daly (Saracens, 47 caps)14. Anthony Watson (Bath Rugby, 46 caps)13. Henry Slade (Exeter Chiefs, 34 caps)12. Ollie Lawrence (Worcester Warriors, 3 caps)11. Jonny May (Gloucester Rugby, 61 caps)10. Owen Farrell (C) (Saracens, 88 caps)9. Ben Youngs (Leicester Tigers, 104 caps)
1. Ellis Genge (Leicester Tigers, 23 caps)2. Jamie George (Saracens, 54 caps)3. Will Stuart (Bath Rugby, 8 caps)4. Maro Itoje (Saracens, 43 caps)5. Jonny Hill (Exeter Chiefs, 4 caps)6. Mark Wilson (Newcastle Falcons, 19 caps)7. Tom Curry (Sale Sharks, 28 caps)8. Billy Vunipola (Saracens, 56 caps)
16. Luke Cowan-Dickie (Exeter Chiefs, 26 caps)17. Beno Obano (Bath Rugby, uncapped)18. Harry Williams (Exeter Chiefs, 18 caps)19. Courtney Lawes (Northampton Saints, 85 caps)20. Ben Earl (Bristol Bears, 8 caps)21. Dan Robson (Wasps, 7 caps)22. George Ford (Leicester Tigers, 72 caps)23. Max Malins (Bristol Bears, 3 caps)
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