Eddie Jones has dropped a third of the England team beaten by Scotland – but kept faith with Owen Farrell and Billy Vunipola.
Captain Farrell does lose the No.10 jersey for Saturday’s home clash with Italy, reverting to centre for his 90th cap in place of the luckless Ollie Lawrence.
But at least he survives, unlike Saracens and Lions team mate Jamie George, who is relegated to the bench after 14 straight starts for his country.
Jones axes the entire front row from the Calcutta Cup defeat, with props Ellis Genge and Will Stuart joining hooker George on the reserve list.
Mako Vunipola returns from injury at loosehead, while Kyle Sinckler is brought straight back after suspension.
In the back row Courtney Lawes replaces blindside flanker Mark Wilson, who is omitted from the matchday squad. But Billy Vunipola, who blamed himself for England's lack of go-forward against Scotland, keeps the No.8 jersey.
Jones described it as his “strongest 23” to take on an opponent who have never beaten England.
He said: “We’re pleased to have Mako and Kyle back into the team and we’ve made some changes to our starting XV, but our finishers are just as important to our game plan. We look at the whole 80 minutes.
“We’ve trained very well this week, I’ve been very pleased with the players’ attitudes and work-rate.”
15. Elliot Daly (Saracens, 48 caps)
14. Anthony Watson (Bath Rugby, 47 caps)
13. Henry Slade (Exeter Chiefs, 35 caps)
12. Owen Farrell (C) (Saracens, 89 caps)
11. Jonny May (Gloucester Rugby, 62 caps)
10. George Ford (Leicester Tigers, 73 caps)
9. Ben Youngs (Leicester Tigers, 105 caps)
1. Mako Vunipola (Saracens, 63 caps)
2. Luke Cowan-Dickie (Exeter Chiefs, 27 caps)
3. Kyle Sinckler (Bristol Bears, 40 caps)
4. Maro Itoje (Saracens, 44 caps)
5. Jonny Hill (Exeter Chiefs, 5 caps)
6. Courtney Lawes (Northampton Saints, 86 caps)
7. Tom Curry (Sale Sharks, 29 caps)
8. Billy Vunipola (Saracens, 57 caps)
16. Jamie George (Saracens, 55 caps)
17. Ellis Genge (Leicester Tigers, 24 caps)
18. Will Stuart (Bath Rugby, 9 caps)
19. Charlie Ewels (Bath Rugby, 17 caps)
20. Ben Earl (Bristol Bears, 9 caps)
21. Jack Willis (Wasps, 2 caps)
22. Dan Robson (Wasps, 8 caps)
23. Max Malins (Bristol Bears, 4 caps)
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